When we open our Bibles to read, we’re never alone. The Holy Spirit hovers over and in the words of God, ready to stir our hearts, illumine our minds, and redirect our lives, all for the glory of Christ (John 16:14). The Spirit is the X factor in Bible reading, making an otherwise ordinary routine supernatural — and making it utterly foolish to read and study without praying for our eyes, minds, and hearts.

Prayer is a conversation, but not one we start. God speaks first. His voice sounds in the Scriptures and climactically in the person and work of his Son. Then, wonder of all wonders, he stops, he stoops, he bends his ear to listen to us. Prayer is almost too good to be true. With our eyes on God’s words, he gives us his ear, too.

How then should we pray over our Bibles? Here are four verses you might pray as you open God’s word.

1. Psalm 119:18: Open My Eyes to Wonder

“Open my eyes, that I may behold wondrous things out of your law” (Psalm 119:18). We ask God to open our spiritual eyes to show us the glimpses of glory we cannot see by ourselves. Without his help, we are simply “natural” persons with natural eyes. “The natural person does not accept the things of the Spirit of God, for they are folly to him, and he is not able to understand [see] them because they are spiritually discerned” (1 Corinthians 2:14).

“The great goal of Bible reading and study is simply this: knowing and enjoying Jesus.”

“Seeing they do not” was Jesus’s phrase for those who saw him and his teaching only with natural eyes, without the illumining work of the Spirit (Matthew 13:13). This is why Paul prays for Christians, “that the God of our Lord Jesus Christ, the Father of glory, may give you the Spirit of wisdom and of revelation in the knowledge of him, having the eyes of your hearts enlightened” (Ephesians 1:17–18).

Join the psalmist in praying not just for the gift of spiritual sight, but for the gift of seeing wondrous things in God’s word. Wonder is a great antidote for wandering. Those who cultivate awe keep their hearts warm and soft, and resist the temptations to grow cold and fall away.

2. Luke 18:38: Have Mercy on Me

Pray, like the blind man begging by the roadside, “Jesus, Son of David, have mercy on me!” (Luke 18:38). For as long as we are in this life, sin encumbers every encounter with God in his word. We fail friends and family daily — and even more, we fail God. So it is fitting to accompany our opening of God’s word with the humble, broken, poor plea of the redeemed: “God, be merciful to me, a sinner!” (Luke 18:13).

Bible reading is a daily prompt to own our failures, newly repent, and freshly cast ourselves on his grace all over again. Prayer is the path to staying fascinated with his grace and cultivating a spirit of true humility.

3. James 1:22: Make Me a Doer of Your Word

Pray that God, having opened your eyes to wonder and reminded you of the sufficiency of his grace, would produce genuine change in your life. Ask him to allow the seeds from Scripture to bear real, noticeable fruit in tangible acts of sacrificial love for others. “Be doers of the word, and not hearers only, deceiving yourselves” (James 1:22). You need not artificially capture one, specific point of application from every passage, but pray that his word would shape and inform and direct your practical living.

Ask that he would make you more manifestly loving, not less, because of the time invested alone in reading and studying his word.

4. Luke 24:45: Open My Eyes to Jesus

This is another way of praying that God would open our eyes to wonder, just with more specificity. The works of God stand as marvelous mountain ranges in the Bible, but the highest peak, and the most majestic vista, is the person and work of his Son.

“Bible reading is a regular prompt to own our failures, repent, and cast ourselves on his grace all over again.”

As Jesus himself taught after his resurrection, he is the Bible’s closest thing to a skeleton key for unlocking the meaning of every text — every book, every plot twist, the whole story. First, “he interpreted to them in all the Scriptures the things concerning himself” (Luke 24:27), then he taught his disciples that “everything written about me in the Law of Moses and the Prophets and the Psalms must be fulfilled” (Luke 24:44). And in doing so, “he opened their minds to understand the Scriptures” (Luke 24:45).

The great goal of Bible reading and study is this: knowing and enjoying Jesus. This is a taste now of heaven’s coming delights. “This is eternal life, that they know you the only true God, and Jesus Christ whom you have sent” (John 17:3). This gives direction, focus, and purpose to our study. “Let us know; let us press on to know the Lord” (Hosea 6:3). This forms great yearning and passion in our souls: “I count everything as loss because of the surpassing worth of knowing Christ Jesus my Lord” (Philippians 3:8).

Keep both eyes peeled for Jesus. Until we see how the passage at hand relates to Jesus’s person and work, we haven’t yet finished the single most important aspect of our reading.

We are desperate for God’s ongoing help to see, and so we pray.